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Questa sindrome pu indicare una tossicit mitocondriale causata dall'infezione da HIV e dai farmaci antiretrovirali assunti per curarla, che a sua volta pu portare ad una carenza di carnitina che influisce sul metabolismo dei lipidi mitocondriali

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In a study of 2.4 g of Cit supplementation per day for eight days in healthy trained men, plasma Arg concentration increased significantly following a cycling exercise protocol, but there was no difference in plasma NO x concentration [126]

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