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Vasoactive intestinal polypeptide is believed to be the principal noncholinergic, nonadrenergic neurotransmitter in the gastrointestinal (GI) tract and has an effect on cholangiocytes to stimulate bicarbonate secretion and increase bile flow [11]

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Microbial proteins are not covered by central tolerance, and their epitopes are highly antigenic, which can bind to host T cell receptor (TCR) and initiate immune response ( In addition, cytokines involved in ICD (such as IFN- and IL-1) and death receptors on the cell surface (such as FAS and TNFR) can also be used as key factors affecting the immune effect ( 2.1.2 ICD adjuvant nature of ICD Adjuvant is another key aspect in ICD process, which determines whether dying cells can effectively recruit and APC, and then start adaptive immune response

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