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once engaged, each receptor fires at native-equivalent peak strength

In addition, this region overlaps with known allosteric motifs, including the X-loop and the GRD motif 30 , both of which also form contacts in IFnarrow (Fig

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In addition, the results from comparative studies on the inhibitory effects of the other thujaplicins ( and ) indicated that van der Waals (VdW) clashes of the isopropyl group of -thujaplicin with Val377 and S380 might reduce the inhibitory activity against hTYR