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However, weight loss from calorie restriction is accompanied by metabolic adaptation, a decrease in metabolic rate below that predicted from the body weight (BW) and composition 2,3,4,5
Lipinska, P., Pawlak, P

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This down-regulation was ameliorated by embelin, in a dose-dependent manner, in comparison with the negative control, and a significant difference was revealed for the 1.2 mg/kg dose of embelin ( Figure 4A )
