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However, the effect of IGF/IGF-1R signaling on stemness and CSCs and the underlying mechanisms are still controversial

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Kiyohara ACP, Torres DJ, Hagiwara A, Pak J, Rueli R, Shuttleworth CWR, Bellinger FP

Mechanistically, chronic hyperinsulinemia resulting from decreased responsiveness to insulin promotes excessive synthesis and release of leptin from adipose tissue (154)
