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Abrine, an IDO1 inhibitor, suppresses the immune escape and enhances the immunotherapy of anti-PD-1 antibody in hepatocellular carcinoma

USA 87 , 71857189 (1990)

IDH1/2 use NADP + as a cofactor and conduct a reversible reaction, while IDH3 uses NAD + as a cofactor and conducts irreversible conversion

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