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Data availability All data supporting the findings of this study are available within the paper and its supplementary information

The idea that SAMe might be helpful for osteoarthritis came from studies of SAMe for depression

The bone microenvironment is important for maintaining normal bone physiology and regulating it in pathological settings

It seems that the Mediterranean diet, composed of a high intake of fruits, vegetables, cereals, and olive oil, with moderate quantities of white meat, fish, and dairy products, and a low intake of sugar and red meat, could be one of the best nutritional patterns