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Simultaneously, the neurons of the activated PVN in the hypothalamus secrete corticotropin-releasing hormone (CRH), which is transported through the hypophyseal portal system where it stimulates the anterior pituitary gland to release adrenocorticotropic hormone (ACTH) into the blood stream

A 5-year clinical outcome study on anti-BCMA CAR T-cell therapy in patients with relapsed/refractory multiple myeloma demonstrated significant efficacy and safety, providing important confidence and a reference point for the potential use of BCMA-targeted CAR T cells in the treatment of autoimmune diseases (114)

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It's a tripeptide protein built from three amino acids: cysteine, glycine, and glutamic acid

Herbal medicinal therapies (e.g., Acorus calamus , Cannabis species, Matricaria chamomilla , Ginkgo biloba , Curcuma longa , Camellia sinensis ) counteract phenomena underlying CIPN, i.e., they reduce oxidative stress and attenuate inflammation in animals [163], but their utility for CIPN prevention requires further investigation to confirm their efficacy and safety [164,165,166,167]