glutathione synthetase deficiency genereview Participation in the Prevention of Cardiovascular Diseases Glutathione synthetase - Wikipedia
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The antioxidant protection it provides helps prevent premature aging caused by environmental damage, while its role in collagen synthesis supports skin firmness and smoothness

10.1016/j.slsci.2015.10.001

Kandiah N, Ong PA, Yuda T, et al

Studies show that melatonin activates receptors to boost P-glycoprotein transporter activity, crucial for BBB function, particularly in methamphetamine-induced toxicity in rat brain endothelial cells [186]