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Any disruptionLow stomach acid (hypochlorhydria), parietal cell loss (atrophic gastritis), IF deficiency (pernicious anemia), or ileal disease (Crohns)can compromise absorption, leading to deficiency risk

A deficiency in *thiamine* can lead to neurological disorders, including peripheral neuropathy, which manifests as numbness, tingling, and weakness

F., Papaconstantinou, J., Fry, C

Heavier individuals may require higher doses to achieve equivalent NNMT inhibition due to larger adipose tissue mass and potentially higher baseline NNMT activity

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