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* Correspondence: Lei Dai [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Their coordinated upregulation indicates a transcriptional reprogramming toward enhanced secondary metabolism, potentially contributing to improved oxidative resilience and adaptive stress responses

Considering the high-pressure, low-oxygen environment within the intervertebral disc, further exploration is needed to determine whether the cells within the scaffold can proliferate normally under such conditions

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