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Triglycerides are the primary lipid form in the livers of patients with NAFLD (Vatner et al., 2015) The primary transcription factors involved in insulin-mediated fat synthesis are Upstream Stimulator Factor (USF) (Wang and Sul, 1997), sterol regulatory element-binding protein-1c (SREBP-1c) (Raghow et al., 2008), carbohydrate response element-binding protein (ChREBP) (Postic et al., 2007), and liver X receptor alpha (LXR)
Nrf2/HO-1, by enhancing iron storage and neutralizing iron toxicity, restricts lipid peroxidation (130)
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