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Within the mitochondria, Copper is conveyed by COX17 to copper-binding proteins SCO1, SCO2, and COX11, thereby assisting in their conveyance to CCO, thereby triggering enzyme activity within the respiratory chain

Therefore, it is likely that mechanisms of protein S -glutathionylation within the cells involves reaction of the critical cysteine on protein or GSH with a corresponding oxidized derivative such as S-nitrosyl ( S -NO), sulfenic acid ( S -OH), thiyl radical ( S )