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Others Other compounds that directly or indirectly affect energy metabolism such as sirtuins prevent fragmentation of mitochondria and promote an increase in ketone levels and are potential therapeutic targets in ALS (Krner et al., 2013a

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Their combined action ensures continuous support against oxidative stress

There are, however, conflicting reports regarding the neuroinvasiveness of SARS-CoV-2 and indeed the cellular expression of the receptors 11,12,13,14,15 , suggesting that other mechanisms are responsible for the neurological problems reported

Morris etal, Pirisoto etal, 2016), and that reduced methylation, such as is seen in autism (due to functional B2/B12 deficiency), and in dementia is associated with intellectual disability (Parkel etal, 2013)
