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Surprisingly, the decrease in GPX4 failed to damage the integrity of both neurons, and mice that only lost GPX4 in AgRP neurons experienced weight gain, while POMC neurons required for ROS buffering and metabolic homeostasis were unaffected by GPX4 deletion (129) ( Figure 2 )

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Early-phase trials should prospectively embed these tools to enable rational dose selection, adaptive decision-making, and go/no-go criteria

However, when ovariectomy was followed by high fat diet, these inflammatory proteins levels were elevated [27]