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For the timepoint study ( n = 50), male and female APOE-TR mice were euthanized at three different timepoint (10-, 25-, and 50-weeks) for three homozygous genotypes: APOE2-TR, APOE3-TR, and APOE4-TR (Supplementary Table S1)

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Although the exact mechanism of action for quinine sulfates effectiveness for the treatment of muscle cramps in patients with cirrhosis is elusive, it has been proposed that it reduces the excitability of the motor nerve by prolonging the refractory period of muscle to repetitive stimuli

Michael Trauner: Conceptualization, Writing- Original draft, Writing- Reviewing and Editing

Vitamin B12 contributes to normal energy metabolism and helps reduce fatigue and tiredness, while zinc supports normal fatty acid metabolism