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The short answer: Yes, but usually mild and rare when taken at recommended doses

Although a great many chronic, inflammatory diseases are recognised as having an oxidative stress component (223) , the history of treating them with antioxidants such as ascorbate has largely been a litany of failure, with the treatment arm often even giving worse prognoses than the placebo (6,223,489501)

Current Opinion in Biotechnology, 65 , 118-128

Only GlyNAC supplementation in OA lowered plasma 8-OHdG by 57% after 2-weeks, and by 73% after 16-weeks (Table 3), and significantly lowered muscle pH2AX after 16-weeks (Figure 2A and B)