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Exosomal escape mechanisms have also been harnessed to deliver CRISPR-Cas9 complexes into resting CD4 T cells, enabling proviral DNA excision with higher efficiency and reduced cytotoxicity compared to standard polymeric carriers

While genome-enabled studies have identified core biosynthetic genes (e.g., CHS-like polyketide synthases) and strong co-expression modules, direct demonstration of specific transcription factors binding and activating anthraquinone biosynthetic promoters is still scarce ( Rheum species has nominated candidate R2R3-MYB and bZIP transcription factors correlated with anthraquinone accumulation, but these studies primarily provide association and expression-based evidence rather than direct TFpromoter validation (Zhao et al., 2024

The skin is then scratched and if you are allergic, a small hive comes up (like a mosquito bite)