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[DOI] [PubMed] [Google Scholar] 82.Food and Nutrition Board

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FIGURE 6 Discussion Diabetes, associated with insulin resistance and reduction in the level of insulin, mainly affects psychomotor activity, attention, learning, memory, cognition, mental flexibility in the brain ( Additionally, the treatment also prevented an increase in the level of APP and neuronal damage

Indeed, mTORC1 directly phosphorylates the unc-51 like autophagy activating kinase 1 (ULK1) [24, 25], an initial regulator of autophagy, and the transcription factor EB (TFEB), a regulator of the expression of lysosomal genes [26,27,28,29], thereby suppressing autophagy and lysosomal degradation