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Obesity also downregulates expression of adiponectin, which promotes insulin sensitivity under healthy conditions (Kawai 2021)
The 2.5 mg starting dose exists purely for gastrointestinal tolerance, not for metabolic effect
[DOI] [PMC free article] [PubMed] [Google Scholar] 167.Deris Zayeri Z., Parsi A., Shahrabi S., Kargar M., Davari N., Saki N
The gut-brain axis, the bidirectional communication between intestinal and central nervous systems, may contribute to symptom generation
