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These immune responses, including the release of pro-inflammatory cytokines (e.g., TNF-, IL-1), can signal to the brain via the vagus nerve and the systemic circulation (Ma et al., 2020)

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Its reduced form, GSH, serves as a potent redox buffer, shielding our DNA, cell lipids, and proteins from the damaging effects of free radicals and peroxides, which can harm cell structures and disrupt metabolic processes

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Macrocircuit dysfunction and redox dysregulation in relation to disrupted myelination and white matter integrity diffusion properties In addition to PV neurons, oligodendrocytes are highly sensitive to altered redox state [155]

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