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Subjects then descended downward, and then ascended upward

This can lead to direct damage to cellular organelles including mitochondria

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In contrast, in the adult human, intravenously administered acetylcarnitine as a bolus (500 mg) led to a rapid increase in plasma concentration followed by a progressive decline reaching the base value in 12 hours

The findings and conclusions presented in this paper are those of the authors and do not necessarily reflect the views of the NIH or the US Department of Health and Human Services