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This radical can isomerize via resonance and reacts with a molecule of NO 2 or O 2 in the gamma position of the nitro group to form a nitronitrite intermediate or a nitro-peroxide intermediate

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Ferroptosis can therefore be induced by depriving cells of the sulfur-containing GSH precursor, cysteine, via inhibition of the system x c cystine/glutamate antiporter (e.g., using small molecules of the erastin family), or by direct inhibition of GPX4 itself (Forcina & Dixon, 2019)