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Given the pharmacokinetic properties previously described, ICA-1s could potentially be used as an oral therapeutic either with or in place of some therapeutics currently in use

Van HMJ, Zhang Y, Thijssen V, Buijs N, Gao Y, Mateuszuk L, Fedak FA, Kij A, Campagna R, Sartini D (2021) Macrocyclic peptides as allosteric inhibitors of nicotinamide N -methyltransferase (NNMT)

So, next time you wake up after a night out, skip the plain water and reach for an electrolyte drinkit just might be your hangover hero

Other mechanisms by which these PPAR agonists prevent oxidative stress include a decrease in iNOS activity, NFB blockade, inhibition of TNF- release, or activation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) 138

Rae-Grant, A