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55 Besides, adropin could promote eNOS activation and perfusion recovery after hindlimb ischemia by upregulating VEGFR2, 56 suppress proliferation and phenotypic modulation of VSMCs induced by angiotensin II via AMPK/ACC signaling, 46 and attenuate vascular calcification by repressing VSMCs osteogenic differentiation through JAK2/STAT3 signaling, 57 as well as inhibit TNF--induced THP1 monocyte adhesion to VECs, prevent macrophages from polarizing into a pro-inflammatory phenotype and reduce the formation of atherosclerotic lesions in apoE / mice

Human gut microbiota/microbiome in health and diseases: a review

(Boston: Elsevier) 303316

Therapeutically, these insights underscore the need for microbiome-responsive strategies

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