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Cell Death Discov 8(1):434 Maaser C, Langholz E, Gordon H, Burisch J, Ellul P, Hernndez V, Karakan T, Katsanos KH, Krustins E, Levine A, Mantzaris GJ, Omorain C, Yuksel ES, Strid H, Annese V (2017) DOP001 European Crohns and Colitis Organisation topical review on environmental factors in IBD

Therefore, model-informed precision dosing targeting cumulative cAUC is essential for optimizing dosing regimens

Specific import of radiolabelled matrix proteins is assessed by the acquisition of an organelle-associated and protease-resistant status

[1] Current clinical treatment options include urate-lowering agents such as allopurinol and febuxostat, as well as anti-inflammatory drugs such as colchicine for acute gout flares

Of the 30 enrolled participants, 26 completed the required study phases and were included in the final analysis