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Sci Am 1997;276:529

The considerable overlap between the series of events that are associated with both apoptosis and necrosis during APAP intoxication, provides the basis of new speculations regarding how APAP actually induces cell death
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On top of this, Glutathione speeds up cell turnover, replacing the damaged cells that give a dark appearance to the skin with new cells

Wu, X., Zhang, Y., Li, Y
