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The sample size consisted of five brains per treatment group of mice

81,82 A meta-analysis of 15 studies with a total of 7,466 men found genetic mutations (commonly known as single nucleotide polymorphisms or SNPs [pronounced snips]) affecting the methylenetetrahydrofolate reductase (MTHFR) gene that regulates folate metabolism were associated with an increased risk of male infertility

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Research into the efficacy of ALA in disease management is mixed