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Numerous signaling proteins have been shown to be succinated including PTEN (phosphatase and tensin homolog)

However, biological barriers such as efflux transporters may limit the absorption of orally administered drugs including peptides

A Phase I trial demonstrated that PX-12 administration is safe and well-tolerated in patients with advanced refractory cancers [228]

Am J Physiol 267, C17231728 (1994)

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