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405 A controlled trial in 10 male subjects found a single dose of a ketone supplement (beta-hydroxybutyrate), which induced ketosis without weight loss, led to a rapid increase in SHBG release compared with placebo

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A loading period usually lasts 3 to 6 months before full effects are observed

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[DOI] [PMC free article] [PubMed] [Google Scholar] 124.Sikiric P., Drmic D., Boban Blagaic A., Tvrdeic A., Krezic I., Gojkovic S., Zizek H., Sikiric S., Strbe S., Smoday I.M., et al