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There is accumulating evidence that coating might reduce eryptosis-inducing properties of nanomaterials [450, 452, 457], which can be exploited to engineer NPs with a better hemocompatibility profile

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Activation of serine/threonine kinase cascade stimulates serine phosphorylation of IRS that in turn impairs tyrosine phosphorylation thus possibly enhancing IRS degradation [144], resulting to alteration of glucose uptake signalling pathways by GLUT4 via IRS-1 and phosphatidylinositol 3-kinase (PI3K)/Akt [137]