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GSH is synthesized in the cellular cytosol from its precursor amino acids Glu, Cys, and Gly, which are brought into the cell by specific transporters (Figure 2A) [12,13,14]

Studies have shown that adding n-3 LCPUFA to TB treatment regimens reduced M.tb burden [50], decreased systemic and lung inflammation [51], and enhanced weight in M.tb -infected C3HeB/FeJ mice with a sufficient n-3 LCPUFA status [52]

Hydroxyl radical is one of the most reactive radicals with a short lifetime, about 10 8 10 9 s

Certain plant-derived polysaccharides (e.g., from Astragalus or Ganoderma lucidum ) promote DNA demethylation of tumor suppressor genes via TET enzymes, inhibit oncogenic histone-modifying enzymes, and regulate cancer-related microRNAs (140)