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Acknowledgments This work was supported in part by the Japan Study Group of NAFLD (JSG-NAFLD, Kyoto, Japan)

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These traditional uses align with its pharmacological properties, as it exhibits anti-inflammatory, anti-cancerous, antiviral, anti-diabetic, anti-asthmatic, and anti-malarial effects [49]

Metabolipidomic profiling using LCMS has demonstrated that circulating levels of several PRLMs, including RvD3, RvD4, RvE3, and 15R-LXA4, are markedly reduced in patients with RA compared with those in healthy controls, with a prominent decrease in RvD3 [254]

Iron overload promotes M1 macrophage transformation through the ROS/acetyl-p53 pathway [94] and induces endothelial dysfunction by ferroptosis, which can be alleviated by DFO (Fig
