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Those who have low levels of Choline have experienced liver damage known as non-alcoholic fatty liver disease, as well as muscle damage and weight gain

While the NIH does not specify a tolerable upper intake level for vitamin B12, a study published in the JAMA Network Open found that high intakes of vitamin B12, such as from daily supplementation of 25 micrograms or higher, increased the risk of bone fracture [3] [4]

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Some people are allergic to one brand of neuromodulator and find that using a different brand works just fine for them

early orthopedic reviews note promise but emphasize the need for rigorous human trials