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Another study in cultured endothelial cells found that short-term exposure to low magnesium media promoted features typically associated with endothelial senescence: cells became enlarged, elongated, and vacuolated, expressed senescence-associated -galactosidase activity, and overexpressed IL-1, considered a marker of endothelial senescence [173]

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Rather SNMG is likely a heterogeneous disease consisting of patients who have pathogenic autoantibodies directed against indeterminate NMJ targets, or known autoantibodies (AChR, MuSK, or LRP4) that are below the level of detection with current commercial diagnostic tests

doi: 10.3899/jrheum.090255 82 NakamuraHMakinoYOkamotoKPoellingerLOhnumaKMorimotoCet al

doi: 10.1016/j.ijbiomac.2023.125165