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Besides serving as a major organ for nutrient digestion and absorption, the single layer of epithelium lining the gastrointestinal tract creates a selective barrier to prevent the transferring of damaging agents as toxins, allergens, and pathogens to the systemic blood circulation [22]

doi: 10.1111/j.1365-2125.2012.04374.x 17

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Given the significant stiffness of the TME, anti-fibrosis emerges as a promising therapeutic approach for augmenting immunotherapy by targeting remodeled ECM components

, Dembicki, J
