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Description
In some embodiments, the otic formulation or composition comprises about 13% by weight of the viscosity modulating agent(s)
These are research pairings observed in the literature, not dosing recommendations
Nature 304 , 368371 (1983)
Some ototoxic agents, such as aminoglycoside-targeting bacteria, also readily damage the mitochondria within cochlear hair cells, resulting in the release of pro-apoptotic factors and oxidative enzymes into the cytoplasm and, consequently, the generation of free radicals (Priuska and Schacht, 1995
author reply e190-192 Scheidegger KJ, James RW, Delafontaine P: Differential effects of low density lipoproteins on insulin-like growth factor-1 (IGF-1) and IGF-1 receptor expression in vascular smooth muscle cells