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Upon recognition of MSU crystals, the NLRP3 inflammasome is activated, leading to the cleavage of pro-inflammatory cytokines, specifically interleukin-1 (IL-1) and interleukin-18 (IL-18)
Sci Rep 14 , 16444 (2024)
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Such changes are linked to the kinetics of the transduction ion channels and voltage-gated ion channels in the axonal membrane [107], affecting the generation and propagation of action potentials [108, 109]
