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Persistent mild inflammation directly leads to disorders of blood glucose regulation and exacerbates complications such as diabetic nephropathy, cardiovascular diseases, and retinopathy through mechanisms such as impairing the function of pancreatic islet cells, aggravating reduced sensitivity to insulin, and promoting vascular endothelial damage (Figure 3)

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Fungal cell wall component -glucan induces IL-1 release by binding to C-type lectin domain containing 7 A (CLEC7A) on Kupffer cells, promoting hepatitis, steatosis, and hepatocyte death, thereby aggravating ALD 16

Endocrinology 141 , 980987 (2000)