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In contrast, T2 low asthma may involve neutrophilic or pauci-granulocytic inflammation with cytokines, such as IL-6, IL-8, IL-17 and tumor necrosis factor alpha (TNF-), playing key roles in neutrophil recruitment and chronic inflammation

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For example, therapeutic use of an inhibitor of histone demethylase LSD1, which is overexpressed in skin epithelial cancer, drives notable increases in H3K4 methylation in the cells, thus leading to both premature epidermal differentiation and the repression of squamous cell carcinoma 34

It gives you clean, round numbers for standard doses easy to measure, hard to mess up