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LRP2 was originally identified as an autoantigen in a rat model of autoimmune kidney disease called Heymann nephritis

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Interestingly, a C-terminal truncation in Ptch1 in adult mice led to a reduction of white fat tissue and PPAR levels, suggesting that the SMO-independent pathway we uncovered might be conserved in mammals 53

Archived from the original on 13 August 2020
