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D., Kauffman, R

However, adjuvant radiation therapy is not beneficial in MPNST survival, even though, in some studies, adjuvant radiation has been used to reduce the tumor size in order to make surgery possible [103]

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A further possible mechanism is that naevomelanocytes originate from neural crest cells destined to become melanocytes in the oral epithelium, but for reasons unknown remain entrapped in the submucosa

For the purpose of this study, we classified sporadic malignant peripheral nerve sheath tumor cases as 'certain' when the diagnosis of malignant peripheral nerve sheath tumor was certain (tumor originating in a peripheral nerve or in a pre-existing nerve sheath tumor, usually a neurofibroma) or focal S100 protein/SOX10 positivity in the absence of other markers and absence of specific simple genomic alteration), or as 'probable' when histologic features was typical but supportive immunohistochemical and clinical data were lacking (not originating from a nerve or benign nerve sheath tumor, absence of S100 protein/SOX10 expression, absence of other immunohistochemical markers, and absence of specific simple genomic alteration)