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It exerts anti-inflammatory effects by inhibiting the gene expression of pro-inflammatory cytokines such as IL-1, IL-1, IL-6, and IL-12p35, downregulating the activity of inflammatory enzymes like iNOS and COX-2, and suppressing key factors in inflammation signaling pathways such as NF-B, FOXO3a, and SIRT1(Parvez et al., 2019)

Moreover, p53 is known to induce the expression of a number of antioxidant genes that would be predicted to suppress ROS accumulation, and therefore counteract ferroptosis [70]

To help prevent B 12 deficiency, encourage all individuals to consume a diet with sufficient B 12

theta to high-fat diet mice regulated gut flora composition, increased gutliver folate levels and hepatic polyunsaturated fatty acid ratio, thereby preventing hepatic steatohepatitis and liver injury