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It is a human monoclonal antibody which targets interleukin 1- beta, and a recent abstract looked at its ability to treat and prevent gout attacks, which showed some success.16 As with Rilonacept above, this agent may have a future role in the acute treatment and relatively short-term prevention of gout, and may have a longer-term role in selected patients with problems with multiple other options

Activated ECs exhibit impaired synthesis or release of EDRFs, resulting in sustained vasoconstriction, reduced vessel diameter, slowed blood flow and impaired pulmonary microcirculation

125,157 Diagnostic approaches include pupillometry for objectively measuring pupil size and reactivity, pharmacological testing to assess responses to agents like pilocarpine, and dynamic pupillometry as a non-invasive biomarker for autonomic dysfunction