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Carnitine palmitoyl transferases execute the step immediately downstream of acyl-CoA synthetase in mitochondrial -oxidation, directly shuttling activated acyl-CoAs into the mitochondrial matrix

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After chronic alcohol exposure, the Aldh2 -deficient mice produce a large amount of harmful oxidized mitochondrial DNA which are delivered into neighboring hepatocellular carcinoma (HCC) cells via extracellular vesicles