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Although IL-1 can be secreted by macrophages to promote Treg expansion, this regulatory mechanism is often disrupted in the inflammatory microenvironment of vitiligo, reducing Treg-mediated suppression of pathogenic T cells
doi: 10.1016/0891-5849(91)90192-6
doi: 10.1016/j.pep.2010.11.010
On activation of IGF-1R or IGF-1R/INSR hybrid receptors, downstream signal transduction occurs via two major pathways (Fig
Tania A
