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Human environmental exposure is often through lead-containing paint, food stored in lead can liners, food stored in ceramic jars, or contaminated water (pipes cast in lead or soldered using lead solder)

In the first step, cysteine and glutamate are linked in a reaction catalyzed by the -glutamylcysteine synthase (-GCS) to form -glutamylcysteine

Thus, we can assume that pathways additional to those involved in angiogenesis (Vukojevic et al., 2018) are associated with the increased expression, internalization of VEGFR2, and the activation of the VEGFR2-Akt-eNOS signaling pathway (Hsieh et al., 2017)

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