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Tirzepatide vs semaglutide 1 mg in T2D SURPASS-2, HbA1c -2.01/-2.24/-2.30 pp, weight dose-responsive while HbA1c saturates: Frias NEJM 2021

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Ice crystal formation denatures the peptide irreversibly Unreconstituted powder (lyophilized): - Store in the freezer at -20 degrees Celsius for maximum shelf life (months to years) - Refrigerated storage at 2 to 8 degrees Celsius is acceptable for several months - Room temperature tolerance: 2 to 4 weeks without significant degradation - Keep the desiccant packet in the container to absorb moisture Practical storage tips: - Store vials on a middle shelf of the refrigerator, not in the door