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Next, cell samples were lysed in a lysis buffer (1% SDS, 10 mM EDTA, 50 mM Tris, and protease inhibitor mixture, pH 8.0)

The therapeutic regimen of the BRAF inhibitor dabrafenib combined with the downstream MEK inhibitor trametinib for NSCLC with metastatic BRAF V600e mutation has been approved by the FDA and European Medicines Agency (EMA) [33]
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Molecular docking analysis revealed that NE and DA could bind to protein disulfide isomerase (PDI)
