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These barriers include borrelial relocation from the midgut of the feeding tick to its body cavity and further to the salivary glands, deposition to the skin, haematogenous dissemination, extravasation from blood circulation system, evasion of the host immune responses, localization to protective niches, and establishment of local as well as distal infection in multiple tissues and organs

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By contrast, BPC 157 largely interacts with the NO system in various models and species, as shown in cytoprotection studies, in particular, studies using both L-NAME and L-arginine as individual agents or in combination[2-4]

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